The Silver Cloud Inn on Lake Union offers stunning view of the lake and downtown, as well as proximity to Eastlake, UW, Capital Hill, City Center and other neighborhoods and points of interest.
There are Silver Cloud Inns in locations all over Washington and Oregon, and all seem to be consistently clean, comfortable, amenity-ed (sic) and reasonably priced.
If you live in the city, your place is probably too small for your in-laws anyway.
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