Hotel's Address in Sikeston, MO Near I-55 Large, illuminating windows and contemporary decor welcome you to the Holiday Inn Express Sikeston. Our hotel's address in Sikeston, MO surrounds you with fun attractions. Thanks to a convenient location near I-55 and nearby companies, business travelers are drawn to our hotel. Sikeston, MO is home to a variety of companies, including John Deere, Monsanto, Orgill, Tyson Foods and Unilever. In addition, we provide guests with a selection of handy services at our state-of-the-art business center. Experience the charm of Sikeston with our hotel's proximity to attractions like Lambert's Cafe, an eatery that's famous for throwing tasty rolls to customers. Sikeston is also home to the annual Sikeston Jaycee Bootheel Rodeo, which draws large crowds every August.